Crystallization (Comment) | Organism |
---|---|
- |
Macaca fascicularis |
Protein Variants | Comment | Organism |
---|---|---|
F279A | the mutation affects inhibition and substrate affinity | Macaca fascicularis |
K97M | mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH | Macaca fascicularis |
K97R | mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH | Macaca fascicularis |
W125A | the mutation affects inhibition and substrate affinity | Macaca fascicularis |
W254A | the mutation affects inhibition and substrate affinity | Macaca fascicularis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-dihydroxyanthraquinone | competitive inhibitor | Macaca fascicularis | |
2,6-dihydroxyanthraquinone | competitive inhibitor | Sus scrofa | |
4-hydroxyacetophenone | competitive inhibitor | Macaca fascicularis | |
4-hydroxyacetophenone | competitive inhibitor | Sus scrofa | |
isoascorbic acid | competitive inhibitor | Macaca fascicularis | |
isoascorbic acid | competitive inhibitor | Sus scrofa | |
L-ascorbic acid | competitive inhibitor | Macaca fascicularis | |
L-ascorbic acid | competitive inhibitor | Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activates | Sus scrofa | |
Mg2+ | activates | Macaca fascicularis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | Q148L6 | - |
- |
Macaca fascicularis | - |
- |
- |
Mus musculus | Q9DBB8 | - |
- |
Pongo abelii | Q5R5J5 | - |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Macaca fascicularis | - |
lens | - |
Mus musculus | - |
additional information | not found in liver and kidney | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
camphorquinone + NAD(P)H | - |
Sus scrofa | (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+ | - |
? | |
camphorquinone + NAD(P)H | - |
Macaca fascicularis | (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+ | - |
? | |
camphorquinone + NAD(P)H | - |
Mus musculus | (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+ | - |
? | |
camphorquinone + NAD(P)H | - |
Pongo abelii | (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+ | - |
? | |
camphorquinone + NAD(P)H | - |
Bos taurus | (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+ | - |
? | |
D-xylose + NADP+ | - |
Sus scrofa | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
D-xylose + NADP+ | - |
Macaca fascicularis | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
D-xylose + NADP+ | - |
Mus musculus | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
D-xylose + NADP+ | - |
Pongo abelii | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
D-xylose + NADP+ | - |
Bos taurus | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Sus scrofa | catechol + NAD(P)H | the reaction produces a ketol which then enolizes to the catechol | ? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Macaca fascicularis | catechol + NAD(P)H | the reaction produces a ketol which then enolizes to the catechol | ? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Mus musculus | catechol + NAD(P)H | the reaction produces a ketol which then enolizes to the catechol | ? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Pongo abelii | catechol + NAD(P)H | the reaction produces a ketol which then enolizes to the catechol | ? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Bos taurus | catechol + NAD(P)H | the reaction produces a ketol which then enolizes to the catechol | ? |
Subunits | Comment | Organism |
---|---|---|
dimer | x-ray crystallography | Sus scrofa |
dimer | x-ray crystallography | Macaca fascicularis |
Synonyms | Comment | Organism |
---|---|---|
DHDH | - |
Sus scrofa |
DHDH | - |
Macaca fascicularis |
DHDH | - |
Mus musculus |
DHDH | - |
Pongo abelii |
DHDH | - |
Bos taurus |
dihydrodiol dehydrogenase | - |
Sus scrofa |
dihydrodiol dehydrogenase | - |
Macaca fascicularis |
dihydrodiol dehydrogenase | - |
Mus musculus |
dihydrodiol dehydrogenase | - |
Pongo abelii |
dihydrodiol dehydrogenase | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Sus scrofa | |
NAD+ | - |
Macaca fascicularis | |
NAD+ | - |
Mus musculus | |
NAD+ | - |
Pongo abelii | |
NAD+ | - |
Bos taurus | |
NADP+ | dependent on | Sus scrofa | |
NADP+ | dependent on | Macaca fascicularis | |
NADP+ | dependent on | Mus musculus | |
NADP+ | dependent on | Pongo abelii | |
NADP+ | dependent on | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.043 | - |
- |
Sus scrofa | isoascorbic acid | |
0.45 | - |
- |
Sus scrofa | L-ascorbic acid |